Capsimax, OmniActive Health Technologies’ Capsicum anuum (pepper) extract standardized for capsaicinoids, was found to support the body’s production of GLP-1 and was associated with improvements in exercise performance and resting energy expenditure in a recent clinical study. The findings were published in the Academic Journal of Sports Science and Medicine.

According to the company, the findings position Capsimax among a few natural ingredients with direct clinical evidence demonstrating activity on natural GLP-1 pathways, building on established benefits for metabolism, appetite management, and fat breakdown.

In the study, 40 resistance-trained men were administered 100 mg of Capsimax over seven days, and were evaluated for exercise performance measures (isometric mid-thigh pulls, barbell squats, push-ups, squats), resting energy expenditure, and changes in GLP-1 concentrations.

Across participants, there was an approximate 13% increase in GLP-1 levels after treatment. There was a significant increase in resting energy expenditure, exceeding +120 kcal/day on day 1, through to day 7. The researchers also reported significant increases in peak force, rate of force development, and average power output.

“These results mark an important evolution for Capsimax as a multi-dimensional ingredient,” said Abhijeet Morde, divisional vice president of in vitro biology, animal studies, and clinicals at OmniActive. “The study reinforces our ability to support consumers who are focused on sustainable weight wellness, whether they’re seeking non-pharmaceutical options, complementing lifestyle changes, or prioritizing energy and performance as part of long-term maintenance.”

“Our findings highlight what truly differentiates Capismax from traditional capsaicin-based ingredients,” said Kratika Gupta, senior vice president of global marketing at OmniActive. “Capsimax delivers thermogenic and metabolic benefits in a way that is effective, well-tolerated, and suitable for everyday use, without the harsh sensory effects that have historically limited capsaicin’s broader application. This allows brands to unlock capsaicin’s benefits in a more consumer-friendly, scalable format.”